Details of the Target

General Information of Target

Target ID LDTP20005
Target Name Kelch-like protein 28 (KLHL28)
Gene Name KLHL28
Gene ID 54813
Synonyms
BTBD5; Kelch-like protein 28; BTB/POZ domain-containing protein 5
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MNTMYVMMAQILRSHLIKATVIPNRVKMLPYFGIIRNRMMSTHKSKKKIREYYRLLNVEE
GCSADEVRESFHKLAKQYHPDSGSNTADSATFIRIEKAYRKVLSHVIEQTNASQSKGEEE
EDVEKFKYKTPQHRHYLSFEGIGFGTPTQREKHYRQFRADRAAEQVMEYQKQKLQSQYFP
DSVIVKNIRQSKQQKITQAIERLVEDLIQESMAKGDFDNLSGKGKPLKKFSDCSYIDPMT
HNLNRILIDNGYQPEWILKQKEISDTIEQLREAILVSRKKLGNPMTPTEKKQWNHVCEQF
QENIRKLNKRINDFNLIVPILTRQKVHFDAQKEIVRAQKIYETLIKTKEVTDRNPNNLDQ
GEGEKTPEIKKGFLNWMNLWKFIKIRSF
Target Bioclass
Other
Uniprot ID
Q9NXS3
Ensemble ID
ENST00000396128.9
HGNC ID
HGNC:19741

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCC1143 SNV: p.K232T .
IGROV1 SNV: p.Y527H .
LNCaP clone FGC SNV: p.A240S .
NB1 SNV: p.I46M .
SW1116 SNV: p.V76A .
SW1271 SNV: p.R213L .
TE1 SNV: p.R213L .
TOV21G Deletion: p.Y200MfsTer3 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
HHS-482
 Probe Info  		Y406(1.02)  LDD2239  [1]

References

1 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.