Details of the Target

General Information of Target

Target ID LDTP20003
Target Name Oxidative stress-responsive serine-rich protein 1 (OSER1)
Gene Name OSER1
Gene ID 51526
Synonyms
C20orf111; Oxidative stress-responsive serine-rich protein 1; Oxidative stress-responsive protein 1; Peroxide-inducible transcript 1 protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGGGWWWARAARLARLRFRRSLLPPQRPRSGGARGSFAPGHGPRAGASPPPVSELDRADA
WLLRKAHETAFLSWFRNGLLASGIGVISFMQSDMGREAAYGFFLLGGLCVVWGSASYAVG
LAALRGPMQLTLGGAAVGAGAVLAASLLWACAVGLYMGQLELDVELVPEDDGTASAEGPD
EAGRPPPE
Target Bioclass
Other
Uniprot ID
Q9NX31
Ensemble ID
ENST00000255174.3
HGNC ID
HGNC:16105

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C56(1.86)  LDD3390  [1]
IPM
 Probe Info  		N.A.  LDD0147  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 HCC1954 C56(1.48)  LDD2343  [1]
 LDCM0023  KB03 P31-FUJ C56(1.48)  LDD2973  [1]
 LDCM0024  KB05 P31-FUJ C56(1.86)  LDD3390  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255