Details of the Target

General Information of Target

Target ID LDTP19987
Target Name Coiled-coil domain-containing protein 177 (CCDC177)
Gene Name CCDC177
Gene ID 56936
Synonyms
C14orf162; PLPL; Coiled-coil domain-containing protein 177; Myelin proteolipid protein-like protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLMPKKNRIAIHELLFKEGVMVAKKDVHMPKHPELADKNVPNLHVMKAMQSLKSRGCVKE
QFAWRHFYWYLTNEGSQYLRDYLHLPPEIVPATLHLPPEIVPATLHRSRPETGRPRPKGL
EGKRPARLTRREADRDTYRRCSVPPGADKKAEAGAGSATEFQFRGRCGRGRGQPPQ
Target Bioclass
Other
Uniprot ID
Q9NQR7
Ensemble ID
ENST00000599174.3
HGNC ID
HGNC:23243

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C58(2.11)  LDD3343  [1]
NAIA_5
 Probe Info  		C100(20.00)  LDD2227  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0632  CL-Sc Hep-G2 C100(20.00)  LDD2227  [2]
 LDCM0022  KB02 COR-L23 C58(1.93)  LDD2310  [1]
 LDCM0023  KB03 COR-L23 C58(1.36)  LDD2727  [1]
 LDCM0024  KB05 NCI-H1299 C58(2.11)  LDD3343  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264