Details of the Target

General Information of Target

Target ID LDTP19930
Target Name Transmembrane protein 121B (TMEM121B)
Gene Name TMEM121B
Gene ID 27439
Synonyms
CECR6; Transmembrane protein 121B; Cat eye syndrome critical region protein 6
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MFVLLYVTSFAICASGQPRGNQLKGENYSPRYICSIPGLPGPPGPPGANGSPGPHGRIGL
PGRDGRDGRKGEKGEKGTAGLRGKTGPLGLAGEKGDQGETGKKGPIGPEGEKGEVGPIGP
PGPKGDRGEQGDPGLPGVCRCGSIVLKSAFSVGITTSYPEERLPIIFNKVLFNEGEHYNP
ATGKFICAFPGIYYFSYDITLANKHLAIGLVHNGQYRIKTFDANTGNHDVASGSTVIYLQ
PEDEVWLEIFFTDQNGLFSDPGWADSLFSGFLLYVDTDYLDSISEDDEL
Target Bioclass
Other
Family
TMEM121 family
Uniprot ID
Q9BXQ6
Ensemble ID
ENST00000331437.4
HGNC ID
HGNC:1844

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 SNV: p.A308T .
CCK81 Deletion: p.G564VfsTer27
SNV: p.L414P		 .
DU145 SNV: p.W198C .
EFO21 SNV: p.A154E .
HCC15 SNV: p.P3T .
HLF SNV: p.P99L .
JHH4 SNV: p.G58C .
MOLT4 Deletion: p.G550EfsTer41 .
NCIH2291 SNV: p.P68A .
NCIH358 SNV: p.S466I .
NCIH716 Substitution: p.N447H .
OVK18 Deletion: p.P22RfsTer111 .
RKO SNV: p.A483T .
SBC5 SNV: p.R187L .
SKMEL28 Substitution: p.S552F .
SW837 SNV: p.R389W .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C475(1.11)  LDD1511  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0281  AC21 HEK-293T C475(1.10)  LDD1520  [1]
 LDCM0289  AC29 HEK-293T C475(1.20)  LDD1528  [1]
 LDCM0298  AC37 HEK-293T C475(1.14)  LDD1537  [1]
 LDCM0307  AC45 HEK-293T C475(1.20)  LDD1546  [1]
 LDCM0312  AC5 HEK-293T C475(1.03)  LDD1551  [1]
 LDCM0316  AC53 HEK-293T C475(1.05)  LDD1555  [1]
 LDCM0325  AC61 HEK-293T C475(1.36)  LDD1564  [1]
 LDCM0248  AKOS034007472 HEK-293T C475(1.11)  LDD1511  [1]
 LDCM0409  CL21 HEK-293T C475(1.27)  LDD1613  [1]
 LDCM0422  CL33 HEK-293T C475(1.85)  LDD1626  [1]
 LDCM0435  CL45 HEK-293T C475(1.53)  LDD1639  [1]
 LDCM0448  CL57 HEK-293T C475(1.38)  LDD1651  [1]
 LDCM0461  CL69 HEK-293T C475(1.11)  LDD1664  [1]
 LDCM0475  CL81 HEK-293T C475(1.43)  LDD1678  [1]
 LDCM0484  CL9 HEK-293T C475(1.22)  LDD1687  [1]
 LDCM0488  CL93 HEK-293T C475(1.20)  LDD1691  [1]

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402