Details of the Target

General Information of Target

Target ID LDTP19913
Target Name UPF0415 protein C7orf25 (C7orf25)
Gene Name C7orf25
Gene ID 79020
Synonyms
UPF0415 protein C7orf25
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAPRLCSISVTARRLLGGPGPRAGDVASAAAARFYSKDNEGSWFRSLFVHKVDPRKDAHS
TLLSKKETSNLYKIQFHNVKPEYLDAYNSLTEAVLPKLHLDEDYPCSLVGNWNTWYGEQD
QAVHLWRFSGGYPALMDCMNKLKNNKEYLEFRRERSQMLLSRRNQLLLEFSFWNEPQPRM
GPNIYELRTYKLKPGTMIEWGNNWARAIKYRQENQEAVGGFFSQIGELYVVHHLWAYKDL
QSREETRNAAWRKRGWDENVYYTVPLVRHMESRIMIPLKISPLQ
Target Bioclass
Other
Family
UPF0415 family
Uniprot ID
Q9BPX7
Ensemble ID
ENST00000350427.5
HGNC ID
HGNC:21703

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
786O SNV: p.Q279Ter .
HCT15 SNV: p.I59T .
HLF SNV: p.K404R .
SNU245 SNV: p.R28T .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C8(1.91)  LDD3332  [1]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 769-P C8(1.70)  LDD2246  [1]
 LDCM0023  KB03 769-P C8(1.97)  LDD2663  [1]
 LDCM0024  KB05 MKN45 C8(1.91)  LDD3332  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Threonine--tRNA ligase 1, cytoplasmic (TARS1) Class-II aminoacyl-tRNA synthetase family P26639
GTP-binding protein 1 (GTPBP1) Classic translation factor GTPase family O00178

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060