Details of the Target

General Information of Target

Target ID LDTP19910
Target Name Proline-rich protein 25 (PRR25)
Gene Name PRR25
Synonyms
Proline-rich protein 25
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGKGNEDPDLHCSSIQCSTDQPPFQQISFTEKGSDEKKPFKEKGKTAFSHSSEKHIQRQG
SEPNPNKENSEETKLKAGNSTAGSEPESSSYRENCRKRKMSSKDSCQDTAGNCPEKECSL
SLNKKSRSSTPVHNSEIQETCDAHHRGRSRACTGRSKRHRSRALGVQTPSIRKSLVTSVR
AMSEAVYQDLAQVWAQQIHSPLTCEQLTLLTRLRGPLCAQVQTLYSMATQAAYVFPAESW
LVPATLPGPGESALDREAHPFPGQEITETVSGSDEAKL
Target Bioclass
Other
Uniprot ID
Q96S07
HGNC ID
HGNC:37230

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C42(1.96)  LDD2347  [1]
Acrolein
 Probe Info  		N.A.  LDD0222  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [2]
 LDCM0022  KB02 HCT 15 C42(1.96)  LDD2347  [1]
 LDCM0023  KB03 HCT 15 C42(2.82)  LDD2764  [1]
 LDCM0024  KB05 HCT 15 C42(2.79)  LDD3181  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.