Details of the Target

General Information of Target

Target ID LDTP19897
Target Name Ganglioside-induced differentiation-associated protein 1-like 1 (GDAP1L1)
Gene Name GDAP1L1
Gene ID 78997
Synonyms
Ganglioside-induced differentiation-associated protein 1-like 1; GDAP1-L1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MASKCSSERKSRTSLTLNQKLEMIKLSEEGMSKAEIGRRLGLLRQTVSQVVNAKEKFLKE
VKSATPMNTRMIRKRNSLIADMEKVLVVWIEDQTSRNIPLSQSLIQNKALTLFNSMKAER
GVEAAEEKFEASRGWFMRFKERSHFHNIKAQGEAASADVEAAASYPEALAKIIDEGGYTK
QQIFNVDETAFYWKKMPSRTFIAREEKSVPGFKASKDRLTLLLGANAAGDFKLKPMLIYH
SENPRALKNYTKSTLPVLYKWNSKARMTAHLFTAWFTEYFKPTVETYCSEKKIPFKILLL
IDNAPSHPRALMEIYEEINVIFMPANTTSILQPMDQGVISTFKSYYLRNTFHKALAAMDS
DVSDGSGQSKLKTFWKGFTILDAIKNIRDSWEEVKLSTLTGVWKKLIPTLIDDYEGFKTS
VEEVSADVVEIAKELELEVEPEDVTELLQSHDKTLTDEELFLMDAQRKWFLEMESTPGED
AVNIVEMTTKDLEYYINLVDKAAAGFERIDSNFERSSTVGKMLSNSIACYREIFHERKSQ
LMRKASPMSYFRKLPQPPQPSAATTLTSQQPSTSRQDPPPAKRVRLTEGSD
Target Bioclass
Other
Family
GST superfamily
Uniprot ID
Q96MZ0
Ensemble ID
ENST00000342560.10
HGNC ID
HGNC:4213

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
MCC26 SNV: p.T321I .
NALM6 SNV: p.A19V .
NCIH2286 SNV: p.L227Q .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C72(1.86)  LDD3340  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 HCC15 C72(1.82)  LDD2340  [1]
 LDCM0023  KB03 Kelly C72(3.04)  LDD2834  [1]
 LDCM0024  KB05 NB1 C72(1.86)  LDD3340  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840