Details of the Target

General Information of Target

Target ID LDTP19863
Target Name Uncharacterized protein MISP3 (MISP3)
Gene Name MISP3
Gene ID 113230
Synonyms
Uncharacterized protein MISP3; MISP family member 3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MVVREASAAQASLSQVLPQLRYLHIFLEQVHTHFQEQSVGERGAAIQLAEGLARQLCTDC
QLNKLFYREEFVLATLLDPCFKGKIEAILPWGPTDIDHWKQVLVYKVKEIRVSEYSLNSP
SPLQSPRGLCVDPTRVAKSSGVEGRSQGEPLQSSSHSGAFLLAQREKGLLESMGLLASER
SGGSLSTKSHWASIIVKKYLWENETVGAQDDPLAYWEKKREAWPPSICLTPHRSLL
Target Bioclass
Other
Family
MISP family
Uniprot ID
Q96FF7
Ensemble ID
ENST00000587086.3
HGNC ID
HGNC:26963

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C139(3.05)  LDD3358  [1]
NAIA_5
 Probe Info  		N.A.  LDD2224  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 22RV1 C139(2.62)  LDD2243  [1]
 LDCM0023  KB03 22RV1 C139(2.66)  LDD2660  [1]
 LDCM0024  KB05 NCI-H2291 C139(3.05)  LDD3358  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264