General Information of Target

Target ID LDTP19811
Target Name UBA-like domain-containing protein 1 (UBALD1)
Gene Name UBALD1
Gene ID 124402
Synonyms
FAM100A; UBA-like domain-containing protein 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLLAPPSTPSRGRTPSAVERLEADKAKYVKTHQVIARRQEPALRGSPGPLTPHPCNELGP
PASPRTPRPVRRGSGRRLPRPDSLIFYRQKRDCKASVNKENAKGQGLVRRLFLGAPRDAA
PSSPASTERPAASGGWAAPQDAPEAAGKRALCPTCSLPLSEKERFFNYCGLERALVEVLG
AERFSPQSWGADASPQAGTSPPPGSGDASDWTSSDRGVDSPGGAGGGGGSEAAGSARDRR
PPVSVVERNARVIQWLYGCQRARGPPRESEV
Target Bioclass
Other
Family
UBALD family
Uniprot ID
Q8TB05
Ensemble ID
ENST00000283474.12
HGNC ID
HGNC:29576

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
LNCaP clone FGC Insertion: p.Q135TfsTer215 .
RT112 SNV: p.A152D .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info 
C23(1.60)  LDD2182  [1]
IPM
 Probe Info 
N.A.  LDD2156  [2]
Acrolein
 Probe Info 
N.A.  LDD0217  [3]
NAIA_5
 Probe Info 
N.A.  LDD2223  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [3]
 LDCM0625  F8 Ramos C23(2.34)  LDD2187  [1]
 LDCM0573  Fragment11 Ramos C23(0.80)  LDD2190  [1]
 LDCM0576  Fragment14 Ramos C23(1.12)  LDD2193  [1]
 LDCM0566  Fragment4 Ramos C23(1.47)  LDD2184  [1]
 LDCM0569  Fragment7 Ramos C23(1.43)  LDD2186  [1]
 LDCM0022  KB02 Ramos C23(1.60)  LDD2182  [1]
 LDCM0024  KB05 Ramos C23(2.00)  LDD2185  [1]

References

1 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
2 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
3 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
4 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264