Details of the Target

General Information of Target

Target ID LDTP19742
Target Name Sterile alpha motif domain-containing protein 12 (SAMD12)
Gene Name SAMD12
Gene ID 401474
Synonyms
Sterile alpha motif domain-containing protein 12; SAM domain-containing protein 12
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MMKEFSSTAQGNTEVIHTGTLQRHESHHIRDFCFQEIEKDIHNFEFQWQEEERNGHEAPM
TEIKELTGSTDRHDQRHAGNKPIKDQLGSSFHSHLPELHIFQPEWKIGNQVEKSIINASL
ILTSQRISCSPKTRISNNYGNNSLHSSLPIQKLGSTHERKIFPM
Target Bioclass
Other
Uniprot ID
Q8N8I0
Ensemble ID
ENST00000314727.9
HGNC ID
HGNC:31750

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Acrolein
 Probe Info  		H20(0.00); K25(0.00)  LDD0233  [1]
NAIA_5
 Probe Info  		N.A.  LDD2223  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0632  CL-Sc Hep-G2 C83(20.00); C8(0.96)  LDD2227  [2]
 LDCM0109  NEM HeLa H20(0.00); K25(0.00)  LDD0233  [1]

References

1 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
2 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264