Details of the Target

General Information of Target

Target ID LDTP19723
Target Name Putative protein N-methyltransferase FAM86B1 (FAM86B1)
Gene Name FAM86B1
Gene ID 85002
Synonyms
Putative protein N-methyltransferase FAM86B1; EC 2.1.1.-
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGQNWKRQQKLWNVPQLPFIRVPPSIYDTSLLKALNQGQQRYFYSIMRIYNSRPQWEALQ
TRYIHSLQHQQLLGYITQREALSYALVLRDSTKRASAKVAPQRTIPRKTSAMTRRCPSVL
PVSVVLPRAQSKRRQVLRN
Target Bioclass
Enzyme
Family
Class I-like SAM-binding methyltransferase superfamily, EEF2KMT family
Uniprot ID
Q8N7N1
Ensemble ID
ENST00000340537.9
HGNC ID
HGNC:28268

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		C256(6.72)  LDD2157  [1]
DBIA
 Probe Info  		C72(2.17)  LDD3321  [2]
Compound 10
 Probe Info  		N.A.  LDD2216  [3]
Compound 11
 Probe Info  		N.A.  LDD2213  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 22RV1 C72(1.65)  LDD2243  [2]
 LDCM0023  KB03 22RV1 C72(1.48)  LDD2660  [2]
 LDCM0024  KB05 SH4 C72(2.17)  LDD3321  [2]

References

1 From chemoproteomic-detected amino acids to genomic coordinates: insights into precise multi-omic data integration. Mol Syst Biol. 2021 Feb;17(2):e9840. doi: 10.15252/msb.20209840.
Mass spectrometry data entry: PXD022151
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279