Details of the Target

General Information of Target

Target ID LDTP19715
Target Name Transmembrane protein 252 (TMEM252)
Gene Name TMEM252
Gene ID 169693
Synonyms
C9orf71; Transmembrane protein 252
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEQPGPRAPDPSLCHHNLQPTDDPNWDSYATTMRTAFTPKTGAVPALIRQNGIRRLGYTY
SLSDPILNQTQYSDEYTWKSHSKEDLIKTETSRGIKSHKSHLNEDIFLWTLPHCQQTGTL
KNCLPWKIPASMKEVNKALSNQFISLTKRDFVDRSKAQKIKKSSHLSLEWKKLLPQPPDT
EFRRNYQIPAKIPELQDFSFKYGCYSSLPVASQGLVPSVLHSYLRNQEHTKKQTTYQSDY
DKTYPDFLMLLNSFTSSQVKEYLQSLSYKDRQIIDRFIRTHCDTNKKKK
Target Bioclass
Other
Subcellular location
Membrane
Uniprot ID
Q8N6L7
Ensemble ID
ENST00000377311.4
HGNC ID
HGNC:28537

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C112(2.24)  LDD3418  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 HuCCT-1 C112(0.78)  LDD2373  [1]
 LDCM0023  KB03 SG231 C112(2.58)  LDD3001  [1]
 LDCM0024  KB05 SG231 C112(2.24)  LDD3418  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840