Details of the Target

General Information of Target

Target ID LDTP19707
Target Name Calcium homeostasis modulator protein 5 (CALHM5)
Gene Name CALHM5
Gene ID 254228
Synonyms
C6orf188; FAM26E; Calcium homeostasis modulator protein 5; Protein FAM26E
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSEAKDNGSRDEVLVPHKNCRKNTTVPGKKGEEKSLAPVFAEKLISPSRRGAKLKDRESH
QENEDRNSELDQDEEDKESFCRGFPMSGCELETSCCVCHSTALGERFC
Target Bioclass
Transporter and channel
Family
CALHM family
Subcellular location
Membrane
Function Pore-forming subunit of a voltage-gated ion channel.
Uniprot ID
Q8N5C1
Ensemble ID
ENST00000368599.4
HGNC ID
HGNC:21568

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Acrolein
 Probe Info  		N.A.  LDD0217  [1]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [1]
Methacrolein
 Probe Info  		N.A.  LDD0218  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [1]
 LDCM0107  IAA HeLa N.A.  LDD0221  [1]

References

1 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.