Details of the Target

General Information of Target

Target ID LDTP19682
Target Name Beta/gamma crystallin domain-containing protein 2 (CRYBG2)
Gene Name CRYBG2
Gene ID 55057
Synonyms
AIM1L; Beta/gamma crystallin domain-containing protein 2; Absent in melanoma 1-like protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MFLTAVNPQPLSTPSWQIETKYSTKVLTGNWMEERRKFTRDTDKTPQSIYRKEYIPFPDH
RPDQISRWYGKRKVEGLPYKHLITHHQEPPHRYLISTYDDHYNRHGYNPGLPPLRTWNGQ
KLLWLPEKSDFPLLAPPTNYGLYEQLKQRQLTPKAGLKQSTYTSSYPRPPLCAMSWREHA
VPVPPHRLHPLPHF
Target Bioclass
Other
Family
Beta/gamma-crystallin family
Uniprot ID
Q8N1P7
Ensemble ID
ENST00000308182.10
HGNC ID
HGNC:17295

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C1567(2.11)  LDD3320  [1]
IA-alkyne
 Probe Info  		C1452(0.00); C1389(0.00); C78(0.00); C1025(0.00)  LDD0162  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 A2780 C604(2.85); C1567(1.08)  LDD2254  [1]
 LDCM0023  KB03 A2780 C604(2.55); C1567(0.88)  LDD2671  [1]
 LDCM0024  KB05 RVH421 C1567(2.11)  LDD3320  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060