Details of the Target

General Information of Target

Target ID LDTP19585
Target Name LanC-like protein 3 (LANCL3)
Gene Name LANCL3
Gene ID 347404
Synonyms
LanC-like protein 3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTRTPVGSARTRPKPRKLGPQRGKALQASSRLSESPALVKKRMPDACTLGRAGIGLPKMC
LHMAVRHSKAQKTGPGILQQRQKPPAPRASGGPALLGKRRGCSEAGSASLEPLSSSRAAA
GCLNQVPLSPFLAGPRNTRRLPAPERERIELAATLCLEGWPLRCLASKGKLHCVY
Target Bioclass
Other
Family
LanC-like protein family
Uniprot ID
Q6ZV70
Ensemble ID
ENST00000378619.4
HGNC ID
HGNC:24767

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CCK81 SNV: p.M75T .
COLO800 SNV: p.L238F .
CORL88 SNV: p.Y128N .
DU145 SNV: p.G233V .
EFO27 SNV: p.Y128H .
HCC44 SNV: p.A131S .
HCT15 SNV: p.A234V .
MELHO SNV: p.L238F .
NCIH1155 SNV: p.V27L .
NCIH82 SNV: p.G124R .
NOMO1 SNV: p.V399E .
OVK18 Deletion: p.Q62RfsTer132 .
TE4 SNV: p.L246I .
U937 SNV: p.E191Ter .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C103(1.58)  LDD2351  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 HEL C103(1.58)  LDD2351  [1]
 LDCM0023  KB03 HEL C103(2.01)  LDD2768  [1]
 LDCM0024  KB05 EoL-1 C103(1.37)  LDD3158  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840