Details of the Target

General Information of Target

Target ID LDTP19560
Target Name Coiled-coil domain-containing protein 73 (CCDC73)
Gene Name CCDC73
Gene ID 493860
Synonyms
Coiled-coil domain-containing protein 73; Sarcoma antigen NY-SAR-79
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLERNLTSMMSVEEPLPRPLTSLYIRLSILERNHMNMTYMAKSSVKIHISKVIIGFVLKR
SLTNVCGKVLSQNSHLVNHQRIHTGEKSYRCHECGKAFTQGSRFINHQIVHTGENFPNVL
NVARLLRMALNSGLTK
Target Bioclass
Other
Uniprot ID
Q6ZRK6
Ensemble ID
ENST00000335185.10
HGNC ID
HGNC:23261

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A375 SNV: p.N480K .
HCT116 Deletion: p.T747LfsTer6 .
HEC1B SNV: p.N338I .
LNCaP clone FGC SNV: p.L375S .
MEWO SNV: p.G106E; p.E454K; p.G964R .
NCIH1793 SNV: p.H182N .
ONS76 SNV: p.Q278H .
OVK18 SNV: p.L779V .
OZ SNV: p.E865G .
REH Insertion: p.S672KfsTer2 .
RKO Deletion: p.T895LfsTer8 .
RPMI7951 SNV: p.G176E .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
N1
 Probe Info  		N1053(0.00); N1059(0.00); N1061(0.00)  LDD0245  [1]

References

1 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.