Details of the Target

General Information of Target

Target ID LDTP19517
Target Name Armadillo-like helical domain containing protein 1 (ARMH1)
Gene Name ARMH1
Gene ID 339541
Synonyms
C1orf228; NCRNA00082; Armadillo-like helical domain containing protein 1; p40
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
METVPPAVDLVLGASACCLACVFTNPLEVVKTRLQLQGELQARGTYPRPYHGFIASVAAV
ARADGLWGLQKGLAAGLLYQGLMNGVRFYCYSLACQAGLTQQPGGTVVAGAVAGALGAFV
GSPAYLIKTQLQAQTVAAVAVGHQHNHQTVLGALETIWRQQGLLGLWQGVGGAVPRVMVG
SAAQLATFASAKAWVQKQQWLPEDSWLVALAGGMISSIAVVVVMTPFDVVSTRLYNQPVD
TAGRGQLYGGLTDCMVKIWRQEGPLALYKGLGPAYLRLGPHTILSMLFWDELRKLAGRAQ
HKGT
Target Bioclass
Other
Uniprot ID
Q6PIY5
Ensemble ID
ENST00000458657.6
HGNC ID
HGNC:34345

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
EFO27 SNV: p.P268L .
HT115 SNV: p.T63A .
IPC298 SNV: p.V102A .
Ishikawa (Heraklio) 02 ER SNV: p.E237A .
LS180 SNV: p.M384V .
MFE319 SNV: p.E101G .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
N1
 Probe Info  		N.A.  LDD0245  [1]

References

1 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.