Details of the Target

General Information of Target

Target ID LDTP19490
Target Name CRACD-like protein (CRACDL)
Gene Name CRACDL
Gene ID 343990
Synonyms
C2orf55; KIAA1211L; CRACD-like protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MASWGGEKRGGAGGSPKPAVYATRKTPSVGSQEDQWYLDYPGDQWSLGFSYSWWKNSVGS
ESKHGEGALDQLQHDVRLEDLGELHRAARSGDVPGVEHVLAPGDTGVDKRDRKKSIQQLV
PEYKEKQTPESLPQNNNPAAPSQAEGGEGGVACGTVEQMTWLCSLPHAVGGGDGDHSSTG
AVGGHPRGPGEYCHLHEQRVHHHIFARGKRKGKNHVSNVVR
Target Bioclass
Other
Uniprot ID
Q6NV74
Ensemble ID
ENST00000397899.7
HGNC ID
HGNC:33454

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
ONAyne
 Probe Info  		K10(0.44)  LDD0274  [1]
STPyne
 Probe Info  		K10(6.67)  LDD0277  [1]
DBIA
 Probe Info  		C118(3.43)  LDD3493  [2]
NAIA_5
 Probe Info  		C728(0.00); C118(0.00)  LDD2224  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 AU565 C118(2.57)  LDD2265  [2]
 LDCM0023  KB03 AU565 C118(2.50)  LDD2682  [2]
 LDCM0024  KB05 ZR-75-1 C118(3.43)  LDD3493  [2]

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264