Details of the Target

General Information of Target

Target ID LDTP19483
Target Name Epididymal-specific lipocalin-12 (LCN12)
Gene Name LCN12
Gene ID 286256
Synonyms
Epididymal-specific lipocalin-12
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MALNNVSLSSGDQRSRVAYRSSHGDLRPRASALAMVSGDGFLVSRPEAIHLGPRQAVRPS
VRAESRRVDGGGRSPREPDGRGRSRQARFSPYPIPAVEPDLLRSVLQQRLIALGGVIAAR
ISV
Target Bioclass
Other
Family
Calycin superfamily, Lipocalin family
Subcellular location
Secreted
Function Binds all-trans retinoic acid and may act as a retinoid carrier protein within the epididymis. May play a role in male fertility.
Uniprot ID
Q6JVE5
Ensemble ID
ENST00000371633.8
HGNC ID
HGNC:28733

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
BTD
 Probe Info  		C165(1.10)  LDD2090  [1]
Acrolein
 Probe Info  		N.A.  LDD0217  [2]
Methacrolein
 Probe Info  		N.A.  LDD0218  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C165(0.85)  LDD2142  [1]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C165(0.94)  LDD2112  [1]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C165(1.28)  LDD2117  [1]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [2]
 LDCM0107  IAA HeLa N.A.  LDD0221  [2]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C165(1.10)  LDD2090  [1]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C165(0.86)  LDD2092  [1]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C165(1.20)  LDD2098  [1]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C165(0.99)  LDD2100  [1]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C165(0.86)  LDD2104  [1]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C165(1.07)  LDD2105  [1]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C165(0.85)  LDD2114  [1]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C165(0.68)  LDD2115  [1]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C165(1.16)  LDD2134  [1]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C165(0.93)  LDD2137  [1]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C165(0.74)  LDD2141  [1]

References

1 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
2 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.