Details of the Target
General Information of Target
| Target ID | LDTP19468 | |||||
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| Target Name | Queuosine-tRNA galactosyltransferase (B3GNTL1) | |||||
| Gene Name | B3GNTL1 | |||||
| Gene ID | 146712 | |||||
| Synonyms |
B3GNT8; QTGAL; Queuosine-tRNA galactosyltransferase; QTGAL; EC 2.4.1.-; Beta-1,3-N-acetylglucosaminyltransferase 8; BGnT-8; Beta-1,3-Gn-T8; Beta3Gn-T8; UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like protein 1; BGnT-like protein 1; Beta1,3-N-acetylglucosaminyltransferase-like protein 1; Beta3Gn-T-like protein 1; Beta3GnTL1
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| 3D Structure | ||||||
| Sequence |
MTARRDPKPGAKRLVRAQTLQKQRRAPVGPRAPPPDEEDPRLKCKNCRALGHTVRSTRCP
MKCWKAALVPPTLGKKEGKENLKPWKPQVEANPGPLNKDKGEKEERPRQQDPQRKALLHI FSGKPPEKLLPNRKGSTESSVFLRVASRPMPVHTTSKRPCVDPELADRSATEMSGRGSVL ASLSPLRKASLRSSSSLGPKERQTGAAADIPQPAVRHQGPEPLLVVKPTHSSREGGCREV PQAASKTHGLLQAVRPQAQDKRPAVTQPGPPAATHSLGLGSNLSFRPGAKRPAQAPIQGC LNFPKKPRLGPFQIPESAIQGGELGALENLQPPPAATELGPSTSPQMGRRTPAQVPGVDR QPPHSRPCLPTAQACTMSHHPAASHDGAQPLRVLFRRLENRRWSSSLLAAPSFHSPEKLG VFLAQSPHVSEKSEGPCVRVPPNVLYEDLQVSSSSEDSDSDLQ |
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| Target Bioclass |
Enzyme
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| Family |
Glycosyltransferase 2 family
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| Function |
Glycosyltransferase that specifically catalyzes galactosylation of cytoplasmic tRNA(Tyr) modified with queuosine at position 34 (queuosine(34)). Galactosylates the cyclopentene hydroxyl group of queuosine(34) in tRNA(Tyr) to form galactosyl-queuosine(34). Mannosylation of queuosine(34) in tRNA(Tyr) is required to slow-down elongation at cognate codons UAC and suppress stop codon readthrough, thereby regulating protein translation.
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| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
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IA-alkyne Probe Info |
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N.A. | LDD0164 | [1] | |