General Information of Target

Target ID LDTP19435
Target Name DDB1- and CUL4-associated factor 12-like protein 1 (DCAF12L1)
Gene Name DCAF12L1
Gene ID 139170
Synonyms
WDR40B; DDB1- and CUL4-associated factor 12-like protein 1; WD repeat-containing protein 40B
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSVEKMTKVEESFQKAMGLKKTVDRWRNSHTHCLWQMALGQRRNPYATLRMQDTMVQELA
LAKKQLLMVRQAALHQLFEKEHQQYQQELNQMGKAFYVERF
Target Bioclass
Other
Family
WD repeat DCAF12 family
Uniprot ID
Q5VU92
Ensemble ID
ENST00000371126.3
HGNC ID
HGNC:29395

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info 
C113(2.00)  LDD3352  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 769-P C270(0.87); C186(0.96)  LDD2246  [1]
 LDCM0023  KB03 769-P C270(0.94); C186(1.17)  LDD2663  [1]
 LDCM0024  KB05 NCI-H1975 C113(2.00)  LDD3352  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840