Details of the Target

General Information of Target

Target ID LDTP19423
Target Name Aspartate beta-hydroxylase domain-containing protein 1 (ASPHD1)
Gene Name ASPHD1
Gene ID 253982
Synonyms
Aspartate beta-hydroxylase domain-containing protein 1; EC 1.14.11.-
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MIQSSQPMSLKLTCSAFRLQRALRFLLGRLPWRVASGARRFRRWLNRYSYTVLSSWPERA
LISLKNRSRFLVRPNTRNRAFSWTCRAARSKPRPRRSTALPRSQASSSRHSWAEFLKFRK
SFQMSNTSQPDPSRPGTERTSSKEAGCRPLGQLDSFSWAARPPPGAAGLAVSEGFFRKIR
SSAPSSPSFSRALMSNTYLCFLTTGPRSSRENTQKSFPATSPREPVTSRLRGKAPALSPS
RELSFTSAPF
Target Bioclass
Enzyme
Family
Aspartyl/asparaginyl beta-hydroxylase family
Subcellular location
Membrane
Uniprot ID
Q5U4P2
Ensemble ID
ENST00000308748.10
HGNC ID
HGNC:27380

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C122(3.48)  LDD3330  [1]
IPM
 Probe Info  		N.A.  LDD0025  [2]
NAIA_5
 Probe Info  		N.A.  LDD2224  [3]
TFBX
 Probe Info  		N.A.  LDD0027  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 22RV1 C122(1.56)  LDD2243  [1]
 LDCM0023  KB03 22RV1 C122(1.95)  LDD2660  [1]
 LDCM0024  KB05 MIA PaCa-2 C122(3.48)  LDD3330  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
3 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264