Details of the Target

General Information of Target

Target ID LDTP19344
Target Name Uncharacterized bromodomain-containing protein 10 (BRD10)
Gene Name BRD10
Gene ID 158358
Synonyms
KIAA2026; Uncharacterized bromodomain-containing protein 10
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGDQRPQDRPSSPGMDSTPWYCDKPPSKYFAKRKHRRLRFPPVDTQNWVFVTEGMDDFRY
GCQSPEDTLVCRRDEFLLPKISLRGPQADPKSRKKKLLKKAALFSKLSPAQPARKAFVEE
VEAQLMTKHPLAMYPNLGEDMPPDLLLQVLKPLDPERKLEDAGSCEGQEKTTDEPTEPGK
YPCGEFSPRPPETRVSCLPPEPPKTPVSSLRPEPPETGVSHLRPQPPKTQVSSLHLEPPE
TGVSHLRPEPPKTQVSSLHLEPPETGVSHLYLEPPGTGVSHLCPEPPKTRVSHLHREPPE
TGVPDLCLEPPKSRVSHLRPEPSETGVSHLHPEPPKTLVSSLHPEPPETGVSHLCPEPPE
TRVSPLRQLPPEAGVSHLCPEPPKTRVPPLRPETPKNGVSPLFPEPPKTRISNLRSEPPK
IGVSHLCLEPPKTRGSHLRPEPPETGVSHLRPEPPKTRVSSLHLEPPETGVSHLCPEPPE
KDVSHLRPEPPDTGVSHLCPEPPKTRVSHLRPEPSETGVSHLRPEPPKILVSSLHQAPPE
SSVSHLRPEPPETGVSHLRPEPPKTRMYSLRPEPPDTGVSHLCPEPPKTRVSSLPPEPPE
TGVSHLCPEPPETRVSHLRPEPPETGVSHLRPEPPKTRMYSLRPEPPNTGVSHLCPEPPK
TRVSSLPPEPPETGVSHLCPEPPETRVSHLRPEPPETGVSRLHPEPPKTRVSSLHAEPPE
SRVSHLCPEPPETGVSHLRPEPPKPRVSSLRPEPLETRVSHLRPEPPETGVSHLHPELPK
PRVSSLHLEPPKTRRVSSLRLEPPKTGRVSSLCPEPTKTGASHLKELFQEGTSSTMECVS
DSLQRRHTSRKLRDFKWAGDLGVNEESISSLFDFTPECRATYQDQKNKKANECSSGLKYS
MELDEMDEVKFFSQEKDLDGKIQNAPNSHSAQHVKMGYGAWYLKPKLGKKLRSDEPLIDP
KLVLEKPDEPDILDGLYGPIAFKDFILSKGYEMPGIIQRLFARRGWTYDSVKTPIQRAMQ
VYKYKEDVTDASEED
Target Bioclass
Other
Uniprot ID
Q5HYC2
Ensemble ID
ENST00000381461.6
HGNC ID
HGNC:23378

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CORL88 SNV: p.G1338E .
GB2 SNV: p.Q375H; p.E395K; p.R503T .
HEC1 SNV: p.I2007N .
HEC1B SNV: p.I2007N .
HT Deletion: p.F1252SfsTer18
SNV: p.S1251P		 .
HT115 Insertion: p.K691EfsTer8 .
IGR37 SNV: p.A711G .
IGR39 SNV: p.A711G .
IGROV1 SNV: p.P1512T .
IM95 SNV: p.P1604T .
IPC298 SNV: p.F1665L .
Ishikawa (Heraklio) 02 ER SNV: p.D942G; p.K1122N .
JURLMK1 SNV: p.N1178D .
KASUMI2 SNV: p.V448A .
KATOIII SNV: p.Q1728R .
LNCaP clone FGC SNV: p.T300A .
LS180 Deletion: p.K729SfsTer15 .
MFE296 SNV: p.E217Ter .
NCIH146 SNV: p.P352L .
NCIH196 Insertion: p.T810YfsTer8 .
NCIH446 SNV: p.C1402F .
REH Insertion: p.K431SfsTer85
SNV: p.K431Ter		 .
SNGM SNV: p.S741T .
SUPT1 Insertion: p.D972Ter .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C400(2.70)  LDD3484  [1]
N1
 Probe Info  		N.A.  LDD0245  [2]
Acrolein
 Probe Info  		N.A.  LDD0217  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0281  AC21 HEK-293T C400(0.95)  LDD1520  [4]
 LDCM0289  AC29 HEK-293T C400(0.90)  LDD1528  [4]
 LDCM0298  AC37 HEK-293T C400(0.95)  LDD1537  [4]
 LDCM0307  AC45 HEK-293T C400(1.09)  LDD1546  [4]
 LDCM0312  AC5 HEK-293T C400(0.73)  LDD1551  [4]
 LDCM0316  AC53 HEK-293T C400(1.16)  LDD1555  [4]
 LDCM0325  AC61 HEK-293T C400(0.91)  LDD1564  [4]
 LDCM0248  AKOS034007472 HEK-293T C400(0.79)  LDD1511  [4]
 LDCM0371  CL102 HEK-293T C400(1.24)  LDD1575  [4]
 LDCM0375  CL106 HEK-293T C400(1.02)  LDD1579  [4]
 LDCM0380  CL110 HEK-293T C400(1.25)  LDD1584  [4]
 LDCM0384  CL114 HEK-293T C400(1.25)  LDD1588  [4]
 LDCM0388  CL118 HEK-293T C400(0.96)  LDD1592  [4]
 LDCM0393  CL122 HEK-293T C400(1.03)  LDD1597  [4]
 LDCM0397  CL126 HEK-293T C400(1.06)  LDD1601  [4]
 LDCM0401  CL14 HEK-293T C400(1.10)  LDD1605  [4]
 LDCM0407  CL2 HEK-293T C400(1.72)  LDD1611  [4]
 LDCM0409  CL21 HEK-293T C400(1.01)  LDD1613  [4]
 LDCM0414  CL26 HEK-293T C400(1.11)  LDD1618  [4]
 LDCM0422  CL33 HEK-293T C400(1.16)  LDD1626  [4]
 LDCM0435  CL45 HEK-293T C400(1.54)  LDD1639  [4]
 LDCM0441  CL50 HEK-293T C400(1.09)  LDD1645  [4]
 LDCM0448  CL57 HEK-293T C400(1.70)  LDD1651  [4]
 LDCM0454  CL62 HEK-293T C400(1.07)  LDD1657  [4]
 LDCM0461  CL69 HEK-293T C400(1.55)  LDD1664  [4]
 LDCM0467  CL74 HEK-293T C400(1.12)  LDD1670  [4]
 LDCM0475  CL81 HEK-293T C400(0.91)  LDD1678  [4]
 LDCM0480  CL86 HEK-293T C400(1.03)  LDD1683  [4]
 LDCM0484  CL9 HEK-293T C400(0.99)  LDD1687  [4]
 LDCM0488  CL93 HEK-293T C400(1.04)  LDD1691  [4]
 LDCM0493  CL98 HEK-293T C400(1.34)  LDD1696  [4]
 LDCM0427  Fragment51 HEK-293T C400(1.02)  LDD1631  [4]
 LDCM0022  KB02 AU565 C400(1.87)  LDD2265  [1]
 LDCM0023  KB03 AU565 C400(2.73)  LDD2682  [1]
 LDCM0024  KB05 UACC-62 C400(2.70)  LDD3484  [1]
 LDCM0109  NEM HeLa N.A.  LDD0231  [3]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
4 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402