General Information of Target

Target ID LDTP19158
Target Name G antigen 1 (GAGE1)
Gene Name GAGE1
Gene ID 2543
Synonyms
G antigen 1; GAGE-1; Antigen MZ2-F; Cancer/testis antigen 4.1; CT4.1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSSLQAMKTLSLVLLVALLSMERAQGLRCYRCLAVLEGASCSVVSCPFLDGVCVSQKVSV
FGSKVRGENKLSLLSCQKDVGFPLLKLTSAVVDSQISCCKGDLCNAVVLAASSPWALCVQ
LLLSLGSVFLWALL
Target Bioclass
Other
Family
GAGE family
Function Antigen, recognized on melanoma by autologous cytolytic T-lymphocytes.
Uniprot ID
P0DTW1
Ensemble ID
ENST00000381700.11
HGNC ID
HGNC:4098

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info 
C117(1.72)  LDD3373  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 KMCH-1 C117(1.99)  LDD2418  [1]
 LDCM0023  KB03 OCUG-1 C117(1.53)  LDD2956  [1]
 LDCM0024  KB05 OCUG-1 C117(1.72)  LDD3373  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840