Details of the Target

General Information of Target

Target ID LDTP19126
Target Name Uncharacterized protein C8orf88 (C8orf88)
Gene Name C8orf88
Gene ID 100127983
Synonyms
Uncharacterized protein C8orf88
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MYGYRRLRSPRDSQTEPQNDNEGETSLATTQMNPPKRRQVEQGPSTGAKKPSISGAPHLN
SYQSLELPQNQQDSGTEELMIVLEQGTEVRLSLEEVILILAPETVLQLTLENTVLVIVPE
HVLRSEDGLQSPVQIQYIIPSVDDFSLEFHAQDGDISDMRRENVPFSPAEEGKAAPLYQQ
PLMIPQANHMAGISPSFLVTPLCIPRCRAAFPQCYPLPPTPSPVGRPRPADSSFSLHGME
LLCTSSLRPMPPSPSPGPQVYHRVHHRPPSRARRCLFRK
Target Bioclass
Other
Uniprot ID
P0DMB2
Ensemble ID
ENST00000517562.3
HGNC ID
HGNC:44672

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C93(2.08)  LDD3392  [1]
NAIA_5
 Probe Info  		N.A.  LDD2223  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 HD-MY-Z C93(1.47)  LDD2348  [1]
 LDCM0023  KB03 HD-MY-Z C93(1.68)  LDD2765  [1]
 LDCM0024  KB05 PANC-1 C93(2.08)  LDD3392  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264