Details of the Target

General Information of Target

Target ID LDTP19060
Target Name Putative methyltransferase-like protein 15P1 (METTL15P1)
Gene Name METTL15P1
Synonyms
METT5D2; Putative methyltransferase-like protein 15P1; EC 2.1.1.-; Methyltransferase 5 domain-containing protein 2; Methyltransferase-like protein 15 pseudogene 1
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MSHQEGSTDGLPDLGTESLFSSPEEQSGAVAATEASSDIDIATSELSVTVTGDGSDSRDG
GFPNDASTENRSSDQESASEDIELESLEDFEHFLMSGESLFHYPLVGEEETEREEEDEEI
QEEGGEEEEEEEEEEEEEEEEEEEEEEQPRAGPQGSGGNHEQYSLEEDQALEEWVSSETS
ALPRPRWQVVTALHQRQLGSRPRFVYEACGARAFVQRFRLQYRLADHVGCVNTVHFNQRG
TRLASSGDDLKVIVWDWVRQRPVLNFESGHTNNVFQAKFLPNCGDSTLAMCARDGQVRVA
ELINASYFNNTKCVAQHRGPAHKLALEPDSPYKFLTSGEDAVVFTIDLRQDRPASKVVVT
RENDKKVGLYTITVNPANTYQFAVGGQDQFVRIYDQRKIDKKENNGVLKKFTPHHLVNCD
FPTNITCVVYSHDGTELLASYNDDDIYLFNSSHSDGAQYSKRFKGHRNNTTVKGVNFYGP
RSEFVVSGSDCGHIFFWEKSSCQIIQFLKGSREGTINCLEPHPYLPVLACSGLDHDVKIW
TPTAKAATELTGLKKVIKKNKWERDEDSLHHGSLFDQYMLWFLLRHVTQRGRHQDWRSGE
AEFPDEESDESSSTSETSEEEVQDRVQCMPS
Target Bioclass
Enzyme
Family
Methyltransferase superfamily, RsmH family
Function Probable S-adenosyl-L-methionine-dependent methyltransferase.
Uniprot ID
P0C7V9
HGNC ID
HGNC:31926

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C172(1.47)  LDD3392  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 A204 C172(1.18)  LDD2252  [1]
 LDCM0023  KB03 A673 C172(8.48)  LDD2678  [1]
 LDCM0024  KB05 PANC-1 C172(1.47)  LDD3392  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840