Details of the Target

General Information of Target

Target ID LDTP18976
Target Name Protein FAM227A (FAM227A)
Gene Name FAM227A
Gene ID 646851
Synonyms
Protein FAM227A
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MWGPGVTAEGLSVAPAPPPLLPLLLLLALALVAPSRGGGGCAELACGERERCCDATNATA
VRCCKLPLHAFLDNVGWFVRKLSGLLILLVLFAIGYFLQRIICPSPRRYPRGQARPGQRP
GPPGGAGPLGGAGPPDDDDDSPALLRDEAAAGSQDSLLDSGGGGRGRGGGGRSDPSCASE
HEMRVVSPVFLQLPSYEEVKYLPTYEESMRLQQLSPGEVVLPVSVLGRPRGGVAAEPDGG
EGRYPLI
Target Bioclass
Other
Family
FAM227 family
Uniprot ID
F5H4B4
Ensemble ID
ENST00000535113.7
HGNC ID
HGNC:44197

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
IM95 Deletion: p.K407SfsTer11 .
MCC26 Substitution: p.P95L .
MEWO SNV: p.M17I .
NCIH1793 Substitution: p.G426L .
SUPT1 SNV: p.K481R .
UACC62 SNV: p.H377L; p.H378N .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
BTD
 Probe Info  		C409(0.64)  LDD2093  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C409(0.64)  LDD2093  [1]

References

1 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761