Details of the Target

General Information of Target

Target ID LDTP18963
Target Name RING finger protein 223 (RNF223)
Gene Name RNF223
Gene ID 401934
Synonyms
RING finger protein 223
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSSSRVGLRLAACLLNVSEAGRKYIVENIAKAALLDKNGKKHPQVSVLNIFSDQDYKRSV
ITIATSVDKLGLAEDLVLHVPGCSVFLFGEADLPEKRSLVQRRKQLGWFTRRDFSALQPD
LGAAPSQRCGLTGSEHGFCFALFFFFF
Target Bioclass
Enzyme
Subcellular location
Membrane
Uniprot ID
E7ERA6
Ensemble ID
ENST00000453464.3
HGNC ID
HGNC:40020

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C116(1.48)  LDD3313  [1]
NAIA_5
 Probe Info  		N.A.  LDD2224  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 ICC18 C116(1.27)  LDD2385  [1]
 LDCM0023  KB03 ICC18 C116(1.65)  LDD2802  [1]
 LDCM0024  KB05 Hs 936.T C116(1.48)  LDD3313  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264