Details of the Target

General Information of Target

Target ID LDTP18949
Target Name Transmembrane protein 232 (TMEM232)
Gene Name TMEM232
Gene ID 642987
Synonyms
Transmembrane protein 232
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDSVAFEDVAVNFTQEEWALLDPSQKNLYREVMQETLRNLTSIGKKWNNQYIEDEHQNPR
RNLRRLIGERLSESKESHQHGEVLTQVPDDTLKKKTPGVQSYESSVCGEIGIGLSSLNRH
LRAFSYSSSLAIHGRTHTGEKPYECKECGKAFRFPSSVRRHERIHSAKKPYECKQCGKAF
SFPSSVRRHERIHSAKKPYECKQCGKALSYLVSFQTHMRMHTGERPHKCNICGKAFFSPS
SLKRHEKSHTGEKRYKCKQCDKAFNCPSSFQYHERTHSGEKPYECTQCRKAFRSVKYLRV
HERKHTGEKPYECKLCGKGFISSTSFRYHEKTHTGEKPYECKKCVKAFSFVKDLRIHERT
HTGEKPFECKQCGKTFTSSNSFHYHERTHTGEKPYECKQCGKAFRSASVLQKHIRTHTGE
KPYGCKQCGKVFRVASQLKMHERTHTGEKPYECKQCGKAFISSNSIRYHKRTHTGEKPYK
CKQCGKAFISSNSFLYHERIHTGEKPYECKQCGKAFRSASILQKHVRTHAG
Target Bioclass
Other
Subcellular location
Membrane
Function Plays a critical role for male fertility and sperm motility by regulating sperm cytoplasm removal and maintaining axoneme integrity.
Uniprot ID
C9JQI7
Ensemble ID
ENST00000455884.7
HGNC ID
HGNC:37270

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A172 SNV: p.R54I .
ABC1 SNV: p.K164Ter .
KYSE150 SNV: p.F332C .
MEWO SNV: p.G258R .
NCIH2170 Substitution: p.E603S .
NCIH716 SNV: p.I543L .
SKMEL30 SNV: p.V144I .
SW756 SNV: p.Q57E .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Acrolein
 Probe Info  		N.A.  LDD0217  [1]

References

1 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.