Details of the Target

General Information of Target

Target ID LDTP18947
Target Name HERV-H LTR-associating protein 1 (HHLA1)
Gene Name HHLA1
Gene ID 10086
Synonyms
HERV-H LTR-associating protein 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEPLGLVVHGKAEPFSAALRSLVNNPRYSDVCFVVGQERQEVFAHRCLLACRCNFFQRLL
GTEPGPGVPSPVVLSTVPTEAFLAVLEFLYTNSVKLYRHSVLEVLTAAVEYGLEELRELC
LQFVVKVLDVDLVCEALQVAVTFGLGQLQERCVAFIEAHSQEALRTRGFLELSAAALLPL
LRSDKLCVDEAELVRAARSWARVGAAVLERPVAEVAAPVVKELRLALLAPAELSALEEQN
RQEPLIPVEQIVEAWKCHALRRGDEARGAPCRRRRGTLPREHHRFLDLSFK
Target Bioclass
Other
Subcellular location
Secreted
Uniprot ID
C9JL84
Ensemble ID
ENST00000414222.2
HGNC ID
HGNC:4904

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A2058 SNV: p.S174F .
HT115 SNV: p.G285C .
KPL1 SNV: p.N85S .
MCF7 SNV: p.N85S .
MEWO SNV: p.R286K .
MFE319 Insertion: p.P343TfsTer33 .
RKO SNV: p.K58N .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		0.82  LDD2182  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0625  F8 Ramos 1.02  LDD2187  [1]
 LDCM0576  Fragment14 Ramos 0.95  LDD2193  [1]
 LDCM0586  Fragment28 Ramos 0.61  LDD2198  [1]
 LDCM0566  Fragment4 Ramos 0.65  LDD2184  [1]
 LDCM0569  Fragment7 Ramos 1.59  LDD2186  [1]
 LDCM0022  KB02 Ramos 0.82  LDD2182  [1]
 LDCM0023  KB03 Ramos 1.51  LDD2183  [1]

References

1 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578