Details of the Target
General Information of Target
| Target ID | LDTP18939 | |||||
|---|---|---|---|---|---|---|
| Target Name | SCRIB overlapping open reading frame protein (SCRIB) | |||||
| Gene Name | SCRIB | |||||
| Synonyms |
SCRIB overlapping open reading frame protein; oSCRIB |
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| 3D Structure | ||||||
| Sequence |
MDVVEVAGSWWAQEREDIIMKYEKGHRAGLPEDKGPKPFRSYNNNVDHLGIVHETELPPL
TAREAKQIRREISRKSKWVDMLGDWEKYKSSRKLIDRAYKGMPMNIRGPMWSVLLNTEEM KLKNPGRYQIMKEKGKRSSEHIQRIDRDVSGTLRKHIFFRDRYGTKQRELLHILLAYEEY NPEVGYCRDLSHIAALFLLYLPEEDAFWALVQLLASERHSLQGFHSPNGGTVQGLQDQQE HVVATSQPKTMGHQDKKDLCGQCSPLGCLIRILIDGISLGLTLRLWDVYLVEGEQALMPI TRIAFKVQQKRLTKTSRCGPWARFCNRFVDTWARDEDTVLKHLRASMKKLTRKQGDLQPP AKPEQGSSASRPVPASRGGKTLCKGDRQAPPGPPARFPRPIWSASPPRAPRSSTPCPGGA VREDTYPVGTQGVPSPALAQGGPQGSWRFLQWNSMPRLPTDLDVEGPWFRHYDFRQSCWV RAISQEDQLAPCWQAEHPAERVRSAFAAPSTDSDQGTPFRARDEQPCAPTSGPCLCGLHL ESSQFPPGF |
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| Target Bioclass |
Other
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| Function |
Represses translation of the downstream SCRIB protein. Translation of oSCRIB hinders SCRIB translation but does not completely abolish it, probably due to leaky scanning which allows the ribosome to bypass the weaker oSCRIB start codon and initiate translation at the stronger SCRIB start codon.
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| Uniprot ID | ||||||
| HGNC ID | ||||||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
|
DBIA Probe Info |
 |
C1082(0.97); C864(4.68) | LDD3310 | [1] | |
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NAIA_5 Probe Info |
 |
C10(0.00); C1082(0.00); C1102(0.00); C864(0.00) | LDD2224 | [2] | |
Competitor(s) Related to This Target
References