Details of the Target

General Information of Target

Target ID LDTP18811
Target Name Leucine-rich repeat-containing protein 14B (LRRC14B)
Gene Name LRRC14B
Gene ID 389257
Synonyms
Leucine-rich repeat-containing protein 14B
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDPAGRARGQGATAGGLLLRAAAAAKGLREDLWGAAALPWRSLSRIPKREGLGEEDTAVA
GHELLLPNERSFQNAAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFL
LKHKARVDVADKHGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHV
RIVEYLIQDLHLKDLNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKGGNTALH
LAAKHGHSPAVQVLLAQWQDINEMNELNISSLQIATRNGHASLVNFLLSENVDLHQKVEP
KESPLHLVVINNHITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVETLLKAGCDL
KAVDKQGKTALAVASRSNHSLVVGMLIKAERYYAWREEHHESIRDPSTGFTLTFKQDHSL
ETRHIRTLLWDLAYHQLKANEWQRLARSWNFTDDQIRAIEEQWSGNESFREHGHRALLIW
LHGTLMTQGDPAKQLYEELVHAGFPKLAEKTRHFKSKTDSNSKKCVVS
Target Bioclass
Other
Family
PRAME family, LRRC14 subfamily
Uniprot ID
A6NHZ5
Ensemble ID
ENST00000328278.4
HGNC ID
HGNC:37268

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C86(2.12); C420(4.88)  LDD3339  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 697 C86(1.54); C413(1.42)  LDD2245  [1]
 LDCM0023  KB03 697 C86(3.69)  LDD2662  [1]
 LDCM0024  KB05 NALM-6 C86(2.12); C420(4.88)  LDD3339  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840