Details of the Target

General Information of Target

Target ID LDTP18792
Target Name DDB1- and CUL4-associated factor 8-like protein 1 (DCAF8L1)
Gene Name DCAF8L1
Gene ID 139425
Synonyms
WDR42B; DDB1- and CUL4-associated factor 8-like protein 1; WD repeat-containing protein 42B
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MARSYGGRVLAAMTLLGIAAAVLAALGAQLLFQLQAGRAELRGLRAEGLGQELGAGPGLP
EDAAGTLLPLAAALAALVLVLGFTCLLLAALCGHLGAELARGPGPRRSDWFLYDCRLLRH
VALGLFCCGISVYLAALSIYALLLFEIETGAAAASILGSGTLVLVAVLTHTLLRAARAAR
RGLHELSPPSFEDDLARPAEVSKASPRAQPQQGIHRRTPYSTCPEPGDPFGSMATATAPA
ALEGGWESSLPASRMHRTLSAGLGHWDGVTHEMRRMLGHRPGSMGKDSTLV
Target Bioclass
Enzyme
Family
WD repeat DCAF8 family
Uniprot ID
A6NGE4
Ensemble ID
ENST00000441525.4
HGNC ID
HGNC:31810

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C209(2.46)  LDD3312  [1]
HHS-465
 Probe Info  		N.A.  LDD2240  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 786-O C209(3.23)  LDD2247  [1]
 LDCM0023  KB03 786-O C209(4.67)  LDD2664  [1]
 LDCM0024  KB05 HMCB C209(2.46)  LDD3312  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010