Details of the Target

General Information of Target

Target ID LDTP18787
Target Name Nuclear envelope integral membrane protein 2 (NEMP2)
Gene Name NEMP2
Gene ID 100131211
Synonyms
TMEM194B; Nuclear envelope integral membrane protein 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKPRTLVELSKLGLGNETVVQLRTLELPVDYREAKRRVTGIWEDHQPQLVVHVGMDTAAK
AIILEQSGKNQGYRDADIRSFWPEGGVCLPGSPDVLESGVCMKAVCKRVAVEGVDVIFSR
DAGRYVCDYTYYLSLHHGKGCAALIHVPPLSRGLPASLLGRALRVIIQEMLEEVGKPKHR
AQFEENSTMVLPAKGN
Target Bioclass
Other
Family
NEMP family
Subcellular location
Nucleus inner membrane
Uniprot ID
A6NFY4
Ensemble ID
ENST00000409150.8
HGNC ID
HGNC:33700

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
KYSE30 SNV: p.V245I .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C34(2.17)  LDD3413  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 Hs 936.T C34(1.73)  LDD2363  [1]
 LDCM0023  KB03 Hs 936.T C34(2.29)  LDD2780  [1]
 LDCM0024  KB05 RVH-421 C34(2.17)  LDD3413  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840