Details of the Target

General Information of Target

Target ID LDTP18747
Target Name Ankyrin repeat domain-containing protein 62 (ANKRD62)
Gene Name ANKRD62
Gene ID 342850
Synonyms
Ankyrin repeat domain-containing protein 62
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLWFQGNSMQLARSSFGLFLRNCSASKTTLPVLTLFTKDPCPLCDEAKEVLKPYENRQPY
KDQKLPGTRRRRSPSSPSHPHMASQSGKRYNLTLNQVLSFDYDMGLDAPKTISSDCGAFY
CLRMFKSPDMTCCFYPKQ
Target Bioclass
Other
Uniprot ID
A6NC57
Ensemble ID
ENST00000587848.3
HGNC ID
HGNC:35241

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CORL88 SNV: p.V685G .
DU4475 SNV: p.W238C .
HT115 SNV: p.A876T .
HT3 SNV: p.E330K .
IGR1 SNV: p.E642K .
IGR37 SNV: p.S345F .
IGR39 SNV: p.S345F .
NALM6 SNV: p.G215E .
OCUG1 SNV: p.D398E .
RKO SNV: p.L76I .
SKMEL5 SNV: p.P30S .
WM2664 Insertion: p.L818TfsTer4 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
BTD
 Probe Info  		C482(0.42)  LDD2141  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C482(0.42)  LDD2141  [1]

References

1 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761