Details of the Target

General Information of Target

Target ID LDTP18722
Target Name Tetraspanin-11 (TSPAN11)
Gene Name TSPAN11
Gene ID 441631
Synonyms
Tetraspanin-11; Tspan-11
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEHKDDDDDDVSFAKWMSSFWGHSWREEDQRGLRERHRLQATSHRKTSLPCPLPVLPRIP
SSDCHPRRHSHEDQEFRCRSHVRDYRKYSEDGSFKEPLESKGRSHSKIEKFSESFERQLC
FRTKRSASLGPESRKERNERECLRMEIKSRKKVEEERSSRKEEHGEAHMAPLFEKGPE
Target Bioclass
Other
Family
Tetraspanin (TM4SF) family
Subcellular location
Membrane
Uniprot ID
A1L157
Ensemble ID
ENST00000261177.10
HGNC ID
HGNC:30795

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C208(1.44)  LDD3380  [1]
BTD
 Probe Info  		C208(0.85)  LDD2105  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 A2780 C208(1.23)  LDD2254  [1]
 LDCM0023  KB03 HKGZ-CC C208(1.30)  LDD2774  [1]
 LDCM0024  KB05 OV-90 C208(1.44)  LDD3380  [1]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C208(0.85)  LDD2105  [2]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761