Details of the Target

General Information of Target

Target ID LDTP18565
Target Name Pleckstrin homology domain-containing family A member 6 (PLEKHA6)
Gene Name PLEKHA6
Gene ID 22874
Synonyms
KIAA0969; PEPP3; Pleckstrin homology domain-containing family A member 6; PH domain-containing family A member 6; Phosphoinositol 3-phosphate-binding protein 3; PEPP-3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MARDLVMFRDVAVDFSQEEWECLNSYQRNLYRDVILENYSNLVSLAGCSISKPDVITLLE
QGKEPWMVVRDEKRRWTLDLESRYDTKKLFQGKDIYEMNLSQWKVMERIKSCGLEEQESP
HEVCFRQVTKTTSEKMPTYRKLTSLPLYQKSHNREKPYECGECGKAFRVRQQLTFHQRIH
TGEKPYECKECGKAFRQCAHLSRHQRIHTSDKLYECKKCGKIFTCGSDLRVHQRIHIGEK
PYECKECGKAFRVRGQLNLHQRIHTGEKPYECKECGKAFRQYAHLTRHQRLNIAEKCYEC
KECGQAFLCSTGLRLHHKLHTGEKPYECKECGKAFRVRQQLTLHQRIHTGEKPYDCKECG
KTFSRGYHLTLHQRIHTGEKPYECKECQKFFRRYSELISHQGIHIGEKPYECKECGKAFR
LFSQLTQHQSIHFGEKPFKCKECEKTFRLLSQLTQHQSIHTGEKPYDCKECGKAFRLHSS
LIQHQRIHSGEKPYKCKECKKAFRQHSHLTYHQRIHNVT
Target Bioclass
Other
Uniprot ID
Q9Y2H5
Ensemble ID
ENST00000272203.8
HGNC ID
HGNC:17053

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Probe 1
 Probe Info  		Y253(11.17); Y930(15.24)  LDD3495  [1]
DBIA
 Probe Info  		C996(1.67)  LDD3314  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [3]
NAIA_5
 Probe Info  		N.A.  LDD2224  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 22RV1 C996(1.84); C1013(1.08)  LDD2243  [2]
 LDCM0023  KB03 22RV1 C996(1.82); C1013(1.02)  LDD2660  [2]
 LDCM0024  KB05 IGR37 C996(1.67)  LDD3314  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ubiquitin-conjugating enzyme E2 Z (UBE2Z) Ubiquitin-conjugating enzyme family Q9H832

References

1 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264