Details of the Target

General Information of Target

Target ID LDTP18552
Target Name Pleckstrin homology domain-containing family H member 1 (PLEKHH1)
Gene Name PLEKHH1
Gene ID 57475
Synonyms
KIAA1200; Pleckstrin homology domain-containing family H member 1; PH domain-containing family H member 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MELSDSDRPVSFGSTSSSASSRDSHGSFGSRMTLVSNSHMGLFNQDKEVGAIKLELIPAR
PFSSSELQRDNPATGQQNADEGSERPPRAQWRVDSNGAPKTIADSATSPKLLYVDRVVQE
ILETERTYVQDLKSIVEDYLDCIRDQTKLPLGTEERSALFGNIQDIYHFNSELLQDLENC
ENDPVAIAECFVSKSEEFHIYTQYCTNYPRSVAVLTECMRNKILAKFFRERQETLKHSLP
LGSYLLKPVQRILKYHLLLHEIENHLDKDTEGYDVVLDAIDTMQRVAWHINDMKRKHEHA
VRLQEIQSLLTNWKGPDLTSYGELVLEGTFRIQRAKNERTLFLFDKLLLITKKRDDTFTY
KAHILCGNLMLVEVIPKEPLSFSVFHYKNPKLQHTVQAKSQQDKRLWVLHLKRLILENHA
AKIPAKAKQAILEMDAIHHPGFCYSPEGGTKALFGSKEGSAPYRLRRKSEPSSRSHKVLK
TSETAQDIQKVSREEGSPQLSSARPSPAQRNSQPSSSTMISVLRAGGALRNIWTDHQIRQ
ALFPSRRSPQENEDDEDDYQMFVPSFSSSDLNSTRLCEDSTSSRPCSWHMGQMESTETSS
SGHRIVRRASSAGESNTCPPEIGTSDRTRELQNSPKTEGQEEMTPFGSSIELTIDDIDHV
YDNISYEDLKLMVAKREEAESTPSKSARDSVRPKSTPELAFTKRQAGHSKGSLYAQTDGT
LSGGEASSQSTHELQAVEENIYDTIGLPDPPSLGFKCSSLKRAKRSTFLGLEADFVCCDS
LRPFVSQDSLQLSEDEAPYHQATPDHGYLSLLYDSPSGNLSMPHKPVSDKLSEEVDEIWN
DLENYIKKNEDKARDRLLAAFPVSKDDVPDRLHAESTPELSRDVGRSVSTLSLPESQALL
TPVKSRAGRASRANCPFEEDLISKEGSFMSLNRLSLASEMPLMDNPYDLANSGLSQTDPE
NPDLGMEATDKTKSRVFMMARQYSQKIKKANQLLKVKSLELEQPPASQHQKSMHKDLAAI
LEEKKQGGPAIGARIAEYSQLYDQIVFRESPLKIQKDGWASPQESSLLRSVSPSQVHHGS
GDWLLHSTYSNGELADFCLPPEQDLRSRYPTFEINTKSTPRQLSAACSVPSLQTSDPLPG
SVQRCSVVVSQPNKENWCQDHLYNSLGRKGISAKSQPYHRSQSSSSVLINKSMDSINYPS
DVGKQQLLSLHRSSRCESHQDLLPDIADSHQQGTEKLSDLTLQDSQKVVVVNRNLPLNAQ
IATQNYFSNFKETDGDEDDYVEIKSEEDESELELSHNRRRKSDSKFVDADFSDNVCSGNT
LHSLNSPRTPKKPVNSKLGLSPYLTPYNDSDKLNDYLWRGPSPNQQNIVQSLREKFQCLS
SSSFA
Target Bioclass
Other
Uniprot ID
Q9ULM0
Ensemble ID
ENST00000329153.10
HGNC ID
HGNC:17733

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
8305C SNV: p.E400K .
A3KAW SNV: p.Y875Ter .
CAL51 Insertion: p.Y183LfsTer49 .
CCK81 SNV: p.T444A .
DOTC24510 SNV: p.R1174S .
DU145 SNV: p.A957T .
HEC1 SNV: p.A169S .
IGROV1 SNV: p.T649A .
IM95 SNV: p.K687N .
JEKO1 SNV: p.G622D .
JURKAT SNV: p.P452H; p.T792I .
KMCH1 SNV: p.H332Q .
KMS27 SNV: p.P318H .
MCC26 SNV: p.A208T .
MEWO Insertion: p.D1064EfsTer11
Substitution: p.P295S		 .
NCIH1155 SNV: p.V710I .
NCIH2172 Substitution: p.H735S .
REH Insertion: p.Y183LfsTer49 .
SKMEL30 SNV: p.P218L .
SNGM SNV: p.G494V .
SUIT2 SNV: p.T412I .
TOV21G SNV: p.P613Q .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C728(2.32)  LDD3413  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 Hs 936.T C707(2.07)  LDD2363  [1]
 LDCM0023  KB03 Hs 936.T C707(3.34)  LDD2780  [1]
 LDCM0024  KB05 RVH-421 C728(2.32)  LDD3413  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840