Details of the Target

General Information of Target

Target ID LDTP18532
Target Name F-box only protein 40 (FBXO40)
Gene Name FBXO40
Gene ID 51725
Synonyms
FBX40; KIAA1195; F-box only protein 40; Muscle disease-related protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAAAAAALESWQAAAPRKRRSAARRPRRREAAPRGREAAPRGREAAPRGPEAEFESDSG
VVLRRIWEAEKDLFISDFWSSALETINRCLTKHLEQLKAPVGTLSDIFGNLHLDSLPEES
DVATDSIPREILVTGTCHLKCVCYGIGNFATCIVARNQLTFLLLLLEKCQIPRSHCWVYD
PLFSQLEIEVLNTLGVTVLSENEEGKRSIRGEPTIFYMLHCGTALYNNLLWSNWSVDALS
KMVIIGNSFKGLEERLLARILQKNYPYIAKILKGLEELEFPQTSQYMDIFNDTSVHWFPV
QKLEQLSIDIWEFREEPDYQDCEDLEIIRNKREDPSATD
Target Bioclass
Other
Subcellular location
Cytoplasm
Function Probable substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex that may function in myogenesis.
Uniprot ID
Q9UH90
Ensemble ID
ENST00000338040.6
HGNC ID
HGNC:29816

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C25(1.09)  LDD2171  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0020  ARS-1620 HCC44 C25(1.09)  LDD2171  [1]
 LDCM0021  THZ1 HCT 116 C25(1.09)  LDD2173  [1]

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.