Details of the Target

General Information of Target

Target ID LDTP18468
Target Name Cerebral cavernous malformations 2 protein-like (CCM2L)
Gene Name CCM2L
Gene ID 140706
Synonyms
C20orf160; Cerebral cavernous malformations 2 protein-like; CCM2-like
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAASRLPPATLTLKQFVRRQQVLLLYRRILQTIRQVPNDSDRKYLKDWAREEFRRNKSAT
EEDTIRMMITQGNMQLKELEKTLALAKS
Target Bioclass
Other
Family
CCM2 family
Uniprot ID
Q9NUG4
Ensemble ID
ENST00000262659.12
HGNC ID
HGNC:16153

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT116 SNV: p.G453C .
HCT15 SNV: p.Q448H .
Ishikawa (Heraklio) 02 ER Deletion: p.D48TfsTer27 .
KMRC20 SNV: p.G364R .
LS180 SNV: p.D160G .
NCIH1993 SNV: p.Y480Ter .
NCIH23 SNV: p.P177H .
NCIH716 Substitution: p.Y480_F481delinsTer .
NUGC3 SNV: p.T197I .
PF382 SNV: p.G265D .
SKMEL28 SNV: p.I305V .
SKNSH SNV: p.P177T .
SNU869 SNV: p.A307V .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C117(1.89)  LDD3478  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 TYK-nu C117(1.23)  LDD2644  [1]
 LDCM0023  KB03 TYK-nu C117(1.43)  LDD3061  [1]
 LDCM0024  KB05 TYK-nu C117(1.89)  LDD3478  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840