Details of the Target

General Information of Target

Target ID LDTP18454
Target Name Lysine-rich coiled-coil protein 1 (KRCC1)
Gene Name KRCC1
Gene ID 51315
Synonyms
CHBP2; Lysine-rich coiled-coil protein 1; Cryptogenic hepatitis-binding protein 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGLKLNGRYISLILAVQIAYLVQAVRAAGKCDAVFKGFSDCLLKLGDSMANYPQGLDDKT
NIKTVCTYWEDFHSCTVTALTDCQEGAKDMWDKLRKESKNLNIQGSLFELCGSGNGAAGS
LLPAFPVLLVSLSAALATWLSF
Target Bioclass
Other
Uniprot ID
Q9NPI7
Ensemble ID
ENST00000347055.4
HGNC ID
HGNC:28039

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C184(1.91)  LDD3369  [1]
NAIA_5
 Probe Info  		C104(0.00); C44(0.00)  LDD2225  [2]
IPM
 Probe Info  		N.A.  LDD2156  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0281  AC21 HEK-293T C75(0.92); C184(1.12)  LDD1520  [4]
 LDCM0289  AC29 HEK-293T C75(0.64); C184(0.81)  LDD1528  [4]
 LDCM0298  AC37 HEK-293T C75(0.92); C184(0.92)  LDD1537  [4]
 LDCM0307  AC45 HEK-293T C75(1.17); C184(1.00)  LDD1546  [4]
 LDCM0312  AC5 HEK-293T C75(1.33); C184(0.94)  LDD1551  [4]
 LDCM0316  AC53 HEK-293T C75(0.75); C184(0.84)  LDD1555  [4]
 LDCM0325  AC61 HEK-293T C75(0.98); C184(1.17)  LDD1564  [4]
 LDCM0248  AKOS034007472 HEK-293T C75(0.86); C184(1.20)  LDD1511  [4]
 LDCM0409  CL21 HEK-293T C75(1.26); C184(1.06)  LDD1613  [4]
 LDCM0422  CL33 HEK-293T C75(0.80); C184(1.04)  LDD1626  [4]
 LDCM0435  CL45 HEK-293T C75(1.10); C184(1.13)  LDD1639  [4]
 LDCM0448  CL57 HEK-293T C75(0.96); C184(1.08)  LDD1651  [4]
 LDCM0461  CL69 HEK-293T C75(0.92); C184(1.15)  LDD1664  [4]
 LDCM0475  CL81 HEK-293T C75(1.33); C184(0.91)  LDD1678  [4]
 LDCM0484  CL9 HEK-293T C75(1.00); C184(0.86)  LDD1687  [4]
 LDCM0488  CL93 HEK-293T C75(0.68); C184(0.89)  LDD1691  [4]
 LDCM0022  KB02 A-549 C184(2.57)  LDD2260  [1]
 LDCM0023  KB03 A-549 C184(1.43)  LDD2677  [1]
 LDCM0024  KB05 OAW-42 C184(1.91)  LDD3369  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Sperm protein associated with the nucleus on the X chromosome N2 (SPANXN2) SPAN-X family Q5MJ10
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Sprouty-related, EVH1 domain-containing protein 1 (SPRED1) . Q7Z699
Uncharacterized protein NKAPD1 (NKAPD1) . Q6ZUT1

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
3 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
4 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402