Details of the Target

General Information of Target

Target ID LDTP18441
Target Name Zinc finger SWIM domain-containing protein 6 (ZSWIM6)
Gene Name ZSWIM6
Gene ID 57688
Synonyms
KIAA1577; Zinc finger SWIM domain-containing protein 6
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAAAGDGGGEGGAGLGSAAGLGPGPGLRGQGPSAEAHEGAPDPMPAALHPEEVAARLQR
MQRELSNRRKILVKNLPQDSNCQEVHDLLKDYDLKYCYVDRNKRTAFVTLLNGEQAQNAI
QMFHQYSFRGKDLIVQLQPTDALLCITNVPISFTSEEFEELVRAYGNIERCFLVYSEVTG
HSKGYGFVEYMKKDFAAKARLELLGRQLGASALFAQWMDVNLLASELIHSKCLCIDKLPS
DYRDSEELLQIFSSVHKPVFCQLAQDEGSYVGGFAVVEYSTAEQAEEVQQAADGMTIKGS
KVQVSFCAPGAPGRSTLAALIAAQRVMHSNQKGLLPEPNPVQIMKSLNNPAMLQVLLQPQ
LCGRAVKPAVLGTPHSLPHLMNPSISPAFLHLNKAHQSSVMGNTSNLFLQNLSHIPLAQQ
QLMKFENIHTNNKPGLLGEPPAVVLQTALGIGSVLPLKKELGHHHGEAHKTSSLIPTQTT
ITAGMGMLPFFPNQHIAGQAGPGHSNTQEKQPATVGMAEGNFSGSQPYLQSFPNLAAGSL
LVGHHKQQQSQPKGTEISSGAASKNQTSLLGEPPKEIRLSKNPYLNLASVLPSVCLSSPA
SKTTLHKTGIASSILDAISQGSESQHALEKCIAYSPPFGDYAQVSSLRNEKRGSSYLISA
PEGGSVECVDQHSQGTGAYYMETYLKKKRVY
Target Bioclass
Other
Function involved in nervous system development, important for striatal morphology and motor regulation.
Uniprot ID
Q9HCJ5
Ensemble ID
ENST00000252744.6
HGNC ID
HGNC:29316

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C970(0.94)  LDD1508  [1]
NAIA_4
 Probe Info  		C57(0.00); C1003(0.00)  LDD2226  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HEK-293T C970(0.94)  LDD1508  [1]
 LDCM0277  AC18 HEK-293T C970(1.16)  LDD1516  [1]
 LDCM0279  AC2 HEK-293T C970(0.85)  LDD1518  [1]
 LDCM0286  AC26 HEK-293T C970(0.83)  LDD1525  [1]
 LDCM0295  AC34 HEK-293T C970(0.92)  LDD1534  [1]
 LDCM0304  AC42 HEK-293T C970(0.75)  LDD1543  [1]
 LDCM0313  AC50 HEK-293T C970(0.93)  LDD1552  [1]
 LDCM0321  AC58 HEK-293T C970(0.95)  LDD1560  [1]
 LDCM0372  CL103 HEK-293T C1100(1.16)  LDD1576  [1]
 LDCM0376  CL107 HEK-293T C1100(1.04)  LDD1580  [1]
 LDCM0381  CL111 HEK-293T C1100(1.13)  LDD1585  [1]
 LDCM0385  CL115 HEK-293T C1100(1.08)  LDD1589  [1]
 LDCM0389  CL119 HEK-293T C1100(1.14)  LDD1593  [1]
 LDCM0394  CL123 HEK-293T C1100(1.15)  LDD1598  [1]
 LDCM0398  CL127 HEK-293T C1100(1.25)  LDD1602  [1]
 LDCM0402  CL15 HEK-293T C1100(1.14)  LDD1606  [1]
 LDCM0405  CL18 HEK-293T C970(1.01)  LDD1609  [1]
 LDCM0415  CL27 HEK-293T C1100(1.16)  LDD1619  [1]
 LDCM0418  CL3 HEK-293T C1100(1.05)  LDD1622  [1]
 LDCM0419  CL30 HEK-293T C970(1.09)  LDD1623  [1]
 LDCM0428  CL39 HEK-293T C1100(1.27)  LDD1632  [1]
 LDCM0432  CL42 HEK-293T C970(0.93)  LDD1636  [1]
 LDCM0445  CL54 HEK-293T C970(0.96)  LDD1648  [1]
 LDCM0451  CL6 HEK-293T C970(1.14)  LDD1654  [1]
 LDCM0455  CL63 HEK-293T C1100(1.17)  LDD1658  [1]
 LDCM0458  CL66 HEK-293T C970(0.88)  LDD1661  [1]
 LDCM0471  CL78 HEK-293T C970(0.91)  LDD1674  [1]
 LDCM0481  CL87 HEK-293T C1100(1.19)  LDD1684  [1]
 LDCM0485  CL90 HEK-293T C970(0.99)  LDD1688  [1]
 LDCM0494  CL99 HEK-293T C1100(1.29)  LDD1697  [1]
 LDCM0495  E2913 HEK-293T C1100(1.15)  LDD1698  [1]
 LDCM0468  Fragment33 HEK-293T C1100(1.29)  LDD1671  [1]

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
2 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264