Details of the Target

General Information of Target

Target ID LDTP18438
Target Name WAP four-disulfide core domain protein 1 (WFDC1)
Gene Name WFDC1
Gene ID 58189
Synonyms
PS20; WAP four-disulfide core domain protein 1; Prostate stromal protein ps20; ps20 growth inhibitor
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAQHDFVPAWLNFSTPQSAKSPTATFEKHGEHLPRGEGRFGVSRRRHNSSDGFFNNGPLR
TAGDSWHQPSLFRHDSVDSGVSKGAYAGITGNPSGWHSSSRGHDGMSQRSGGGTGNHRHW
NGSFHSRKGCAFQEKPPMEIREEKKEDKVEKLQFEEEDFPSLNPEAGKQHQPCRPIGTPS
GVWENPPSAKQPSKMLVIKKVSKEDPAAAFSAAFTSPGSHHANGNKLSSVVPSVYKNLVP
KPVPPPSKPNAWKANRMEHKSGSLSSSRESAFTSPISVTKPVVLASGAALSSPKESPSST
TPPIEISSSRLTKLTRRTTDRKSEFLKTLKDDRNGDFSENRDCDKLEDLEDNSTPEPKEN
GEEGCHQNGLALPVVEEGEVLSHSLEAEHRLLKAMGWQEYPENDENCLPLTEDELKEFHM
KTEQLRRNGFGKNGFLQSRSSSLFSPWRSTCKAEFEDSDTETSSSETSDDDAWK
Target Bioclass
Other
Subcellular location
Secreted
Function Has growth inhibitory activity.
Uniprot ID
Q9HC57
Ensemble ID
ENST00000219454.10
HGNC ID
HGNC:15466

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TFBX
 Probe Info  		N.A.  LDD0027  [1]
DBIA
 Probe Info  		C66(12.21); C78(4.32); C83(3.78); C89(2.35)  LDD2236  [2]

References

1 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
2 Global profiling of phosphorylation-dependent changes in cysteine reactivity. Nat Methods. 2022 Mar;19(3):341-352. doi: 10.1038/s41592-022-01398-2. Epub 2022 Feb 28.
Mass spectrometry data entry: PXD026730