Details of the Target

General Information of Target

Target ID LDTP18411
Target Name DnaJ homolog subfamily C member 18 (DNAJC18)
Gene Name DNAJC18
Gene ID 202052
Synonyms
DnaJ homolog subfamily C member 18
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEPQLGPEAAALRPGWLALLLWVSALSCSFSLPASSLSSLVPQVRTSYNFGRTFLGLDKC
NACIGTSICKKFFKEEIRSDNWLASHLGLPPDSLLSYPANYSDDSKIWRPVEIFRLVSKY
QNEISDRRICASASAPKTCSIERVLRKTERFQKWLQAKRLTPDLVQGLASPLLRCPSQRL
LDRVVRRYAEVADAGSIFMDHFTDRDKLRLLYTLAVNSHPILLQIFPGAEGWPLPKYLGS
CGRFLVSTSTRPLQEFYDAPPDQAADLAYQLLGVLESLRSNDLNYFFYFTHIDAGMFGVF
NNGHLFIRDASAVGVIDKQEGSQEANRAGENKDIFSCLVSGCQAQLPSCESISEKQSLVL
VCQKLLPRLLQGRFPSPVQDDIDSILVQCGDSIRPDPEVLGAASQLKDILRPLRTCDSRF
AYRYPDCKYNDKF
Target Bioclass
Other
Subcellular location
Endoplasmic reticulum membrane
Function
In case of infection by polyomavirus, involved in the virus endoplasmic reticulum membrane penetration and infection. Regulates the recruitment of DNAJB12:DNAJB14 into SV40-induced foci and all cooperate to guide SV40 across the endoplasmic reticulum membrane. The foci represent the site from which SV40 penetrates into the cytosol.
Uniprot ID
Q9H819
Ensemble ID
ENST00000302060.10
HGNC ID
HGNC:28429

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C115(1.13)  LDD1575  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0371  CL102 HEK-293T C115(1.13)  LDD1575  [1]
 LDCM0375  CL106 HEK-293T C115(1.12)  LDD1579  [1]
 LDCM0380  CL110 HEK-293T C115(0.96)  LDD1584  [1]
 LDCM0384  CL114 HEK-293T C115(0.93)  LDD1588  [1]
 LDCM0388  CL118 HEK-293T C115(0.88)  LDD1592  [1]
 LDCM0393  CL122 HEK-293T C115(1.16)  LDD1597  [1]
 LDCM0397  CL126 HEK-293T C115(0.94)  LDD1601  [1]
 LDCM0401  CL14 HEK-293T C115(1.56)  LDD1605  [1]
 LDCM0407  CL2 HEK-293T C115(1.28)  LDD1611  [1]
 LDCM0414  CL26 HEK-293T C115(1.15)  LDD1618  [1]
 LDCM0441  CL50 HEK-293T C115(1.23)  LDD1645  [1]
 LDCM0454  CL62 HEK-293T C115(1.43)  LDD1657  [1]
 LDCM0467  CL74 HEK-293T C115(1.32)  LDD1670  [1]
 LDCM0480  CL86 HEK-293T C115(1.47)  LDD1683  [1]
 LDCM0493  CL98 HEK-293T C115(0.98)  LDD1696  [1]
 LDCM0427  Fragment51 HEK-293T C115(1.29)  LDD1631  [1]

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402