Details of the Target
General Information of Target
| Target ID | LDTP18405 | |||||
|---|---|---|---|---|---|---|
| Target Name | Ankyrin repeat and SOCS box protein 8 (ASB8) | |||||
| Gene Name | ASB8 | |||||
| Gene ID | 140461 | |||||
| Synonyms |
Ankyrin repeat and SOCS box protein 8; ASB-8 |
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| 3D Structure | ||||||
| Sequence |
MPSLWREILLESLLGCVSWSLYHDLGPMIYYFPLQTLELTGLEGFSIAFLSPIFLTITPF
WKLVNKKWMLTLLRIITIGSIASFQAPNAKLRLMVLALGVSSSLIVQAVTWWSGSHLQRY LRIWGFILGQIVLVVLRIWYTSLNPIWSYQMSNKVILTLSAIATLDRIGTDGDCSKPEEK KTGEVATGMASRPNWLLAGAAFGSLVFLTHWVFGEVSLVSRWAVSGHPHPGPDPNPFGGA VLLCLASGLMLPSCLWFRGTGLIWWVTGTASAAGLLYLHTWAAAVSGCVFAIFTASMWPQ TLGHLINSGTNPGKTMTIAMIFYLLEIFFCAWCTAFKFVPGGVYARERSDVLLGTMMLII GLNMLFGPKKNLDLLLQTKNSSKVLFRKSEKYMKLFLWLLVGVGLLGLGLRHKAYERKLG KVAPTKEVSAAIWPFRFGYDNEGWSSLERSAHLLNETGADFITILESDASKPYMGNNDLT MWLGEKLGFYTDFGPSTRYHTWGIMALSRYPIVKSEHHLLPSPEGEIAPAITLTVNISGK LVDFVVTHFGNHEDDLDRKLQAIAVSKLLKSSSNQVIFLGYITSAPGSRDYLQLTEHGNV KDIDSTDHDRWCEYIMYRGLIRLGYARISHAELSDSEIQMAKFRIPDDPTNYRDNQKVVI DHREVSEKIHFNPRFGSYKEGHNYENNHHFHMNTPKYFL |
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| Target Bioclass |
Other
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| Family |
Ankyrin SOCS box (ASB) family
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| Subcellular location |
Cytoplasm
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| Function |
May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
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| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
|
DBIA Probe Info |
 |
C133(1.77) | LDD3487 | [1] | |
|
IA-alkyne Probe Info |
 |
N.A. | LDD0161 | [2] | |
|
TFBX Probe Info |
 |
N.A. | LDD0148 | [3] | |
Competitor(s) Related to This Target
References