Details of the Target

General Information of Target

Target ID LDTP18399
Target Name Ras-related and estrogen-regulated growth inhibitor-like protein (RERGL)
Gene Name RERGL
Gene ID 79785
Synonyms
Ras-related and estrogen-regulated growth inhibitor-like protein; EC 3.6.5.2; RERG/Ras-like protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLREFSKWGVEASPGKAWERKRSLLRGAVGRYRGATGGDLFWAPFPSWGTMEFPEHSQQL
LQSLREQRSQGFLCDCTVMVGSTQFLAHRAVLASCSPFFQLFYKERELDKRDLVCIHNEI
VTAPAFGLLLDFMYAGQLTLRGDTPVEDVLAAASYLHMNDIVKVCKRRLQARALAEADST
KKEEETNSQLPSLEFLSSTSRGTQPSLASAETSGHWGKGEWKGSAAPSPTVRPPDEPPMS
SGADTTQPGMEVDAPHLRAPHPPVADVSLASPSSSTETIPTNYFSSGISAVSLEPLPSLD
VGPESLRVVEPKDPGGPLQGFYPPASAPTSAPAPVSAPVPSQAPAPAEAELVQVKVEAIV
ISDEETDVSDEQPQGPERAFPSGGAVYGAQPSQPEAFEDPGAAGLEEVGPSDHFLPTDPH
LPYHLLPGAGQYHRGLVTSPLPAPASLHEPLYLSSEYEAAPGSFGVFTEDVPTCKTCGKT
FSCSYTLRRHATVHTRERPYECRYCLRSYTQSGDLYRHIRKAHNEDLAKRSKPDPEVGPL
LGVQPLPGSPTADRQSSSGGGPPKDFVLAPKTNI
Target Bioclass
Enzyme
Family
Small GTPase superfamily, Ras family
Function Binds GDP/GTP and may possess intrinsic GTPase activity.
Uniprot ID
Q9H628
Ensemble ID
ENST00000229002.6
HGNC ID
HGNC:26213

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
BTD
 Probe Info  		C128(1.11)  LDD2096  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C128(1.11)  LDD2096  [1]

References

1 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761