Details of the Target

General Information of Target

Target ID LDTP18397
Target Name Actin-like protein 8 (ACTL8)
Gene Name ACTL8
Gene ID 81569
Synonyms
Actin-like protein 8; Cancer/testis antigen 57; CT57
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGSQTMAVALPRDLRQDANLAKRRHAELCRQKRVFNARNRIIGGDTEAWDVQVHDQKIKE
ATEKARHETFAAEMRQNDKIMCILENRKKRDRKNLCRAINDFQQSFQKPETRREFDLSDP
LALKKDLPARQSDNDVRNTISGMQKFMGEDLNFHERKKFQEEQNREWSLQQQREWKNARA
EQKCAEALYTETRLQFDETAKHLQKLESTTRKAVCASVKDFNKSQAIESVERKKQEKKQE
QEDNLAEITNLLRGDLLSENPQQAASSFGPHRVVPDRWKGMTQEQLEQIRLVQKQQIQEK
LRLQEEKRQRDLDWDRRRIQGARATLLFERQQWRRQRDLRRALDSSNLSLAKEQHLQKKY
MNEVYTNQPTGDYFTQFNTGSR
Target Bioclass
Other
Family
Actin family
Subcellular location
Cytoplasm, cytoskeleton
Uniprot ID
Q9H568
Ensemble ID
ENST00000375406.2
HGNC ID
HGNC:24018

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C197(1.40); C58(1.49)  LDD3347  [1]
m-APA
 Probe Info  		N.A.  LDD2231  [2]
IA-alkyne
 Probe Info  		C197(0.00); C212(0.00); C58(0.00); C38(0.00)  LDD0162  [3]
IPM
 Probe Info  		C197(0.00); C58(0.00)  LDD0147  [4]
TFBX
 Probe Info  		N.A.  LDD0148  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 786-O C38(1.25); C197(1.49); C58(1.48)  LDD2247  [1]
 LDCM0023  KB03 786-O C38(2.67); C197(3.07)  LDD2664  [1]
 LDCM0024  KB05 NCI-H1703 C197(1.40); C58(1.49)  LDD3347  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ceramide transfer protein (CERT1) . Q9Y5P4

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255