Details of the Target

General Information of Target

Target ID LDTP18379
Target Name WD repeat-containing protein 13 (WDR13)
Gene Name WDR13
Gene ID 64743
Synonyms
WD repeat-containing protein 13
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MVFCLSSEEPRRPLRSDMVHFQASEVQQLLHNKFVVILGDSIQRAVYKDLVLLLQKDSLL
TAAQLKAKGELSFEQDQLVAGGQLGELHNGTQYREVRQFCSGSGHHLVRFYFLTRVYSEY
LEDVLEELTYGPAPDLVIINSCLWDLSRYGRCSMESYRENLERVFVRMDQVLPDSCLLVW
NMAMPLGERITGGFLLPELQPLAGSLRRDVVEGNFYSATLAGDHCFDVLDLHFHFRHAVQ
HRHRDGVHWDQHAHRHLSHLLLTHVADAWGVELPKRGYPPDPWIEDWAEMNHPFQGSHRQ
TPDFGEHLALLPPPPSSLPPPMPFPYPLPQPSPPPLFPPLPQDTPFFPGQPFPPHEFFNY
NPVEDFSMPPHLGCGPGVNFVPGPLPPPIPGPNPHGQHWGPVVHRGMPRYVPNSPYHVRR
MGGPCRQRLRHSERLIHTYKLDRRPPAHSGTWPG
Target Bioclass
Other
Subcellular location
Nucleus
Uniprot ID
Q9H1Z4
Ensemble ID
ENST00000218056.9
HGNC ID
HGNC:14352

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K396(8.33)  LDD0277  [1]
Acrolein
 Probe Info  		N.A.  LDD0223  [2]
DBIA
 Probe Info  		C423(0.99); C432(0.99)  LDD0078  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [4]
NAIA_5
 Probe Info  		C377(0.00); C413(0.00)  LDD2223  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0226  AC11 HEK-293T C413(1.04)  LDD1509  [6]
 LDCM0278  AC19 HEK-293T C413(0.92)  LDD1517  [6]
 LDCM0287  AC27 HEK-293T C413(0.94)  LDD1526  [6]
 LDCM0290  AC3 HEK-293T C413(0.84)  LDD1529  [6]
 LDCM0296  AC35 HEK-293T C413(1.04)  LDD1535  [6]
 LDCM0305  AC43 HEK-293T C413(0.98)  LDD1544  [6]
 LDCM0314  AC51 HEK-293T C413(0.91)  LDD1553  [6]
 LDCM0322  AC59 HEK-293T C413(0.93)  LDD1561  [6]
 LDCM0020  ARS-1620 HCC44 C423(0.99); C432(0.99)  LDD0078  [3]
 LDCM0367  CL1 HEK-293T C413(1.06)  LDD1571  [6]
 LDCM0370  CL101 HEK-293T C413(1.71)  LDD1574  [6]
 LDCM0374  CL105 HEK-293T C413(1.30)  LDD1578  [6]
 LDCM0378  CL109 HEK-293T C413(0.90)  LDD1582  [6]
 LDCM0383  CL113 HEK-293T C413(1.26)  LDD1587  [6]
 LDCM0387  CL117 HEK-293T C413(1.41)  LDD1591  [6]
 LDCM0392  CL121 HEK-293T C413(1.24)  LDD1596  [6]
 LDCM0396  CL125 HEK-293T C413(1.14)  LDD1600  [6]
 LDCM0400  CL13 HEK-293T C413(0.81)  LDD1604  [6]
 LDCM0406  CL19 HEK-293T C413(0.83)  LDD1610  [6]
 LDCM0413  CL25 HEK-293T C413(1.01)  LDD1617  [6]
 LDCM0420  CL31 HEK-293T C413(0.93)  LDD1624  [6]
 LDCM0426  CL37 HEK-293T C413(1.06)  LDD1630  [6]
 LDCM0433  CL43 HEK-293T C413(0.85)  LDD1637  [6]
 LDCM0439  CL49 HEK-293T C413(1.25)  LDD1643  [6]
 LDCM0446  CL55 HEK-293T C413(0.96)  LDD1649  [6]
 LDCM0453  CL61 HEK-293T C413(1.13)  LDD1656  [6]
 LDCM0459  CL67 HEK-293T C413(0.88)  LDD1662  [6]
 LDCM0462  CL7 HEK-293T C413(0.74)  LDD1665  [6]
 LDCM0466  CL73 HEK-293T C413(1.09)  LDD1669  [6]
 LDCM0472  CL79 HEK-293T C413(0.92)  LDD1675  [6]
 LDCM0479  CL85 HEK-293T C413(0.79)  LDD1682  [6]
 LDCM0486  CL91 HEK-293T C413(0.89)  LDD1689  [6]
 LDCM0492  CL97 HEK-293T C413(0.72)  LDD1695  [6]
 LDCM0022  KB02 769-P C413(2.25)  LDD2246  [7]
 LDCM0023  KB03 769-P C413(2.94)  LDD2663  [7]
 LDCM0024  KB05 MKN45 C413(1.90)  LDD3332  [7]
 LDCM0109  NEM HeLa N.A.  LDD0223  [2]

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
6 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
7 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840