Details of the Target

General Information of Target

Target ID LDTP18346
Target Name Transmembrane 6 superfamily member 1 (TM6SF1)
Gene Name TM6SF1
Gene ID 53346
Synonyms
Transmembrane 6 superfamily member 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPGEATETVPAIEQQLLQPQAETGSGTESDSDESVPELEEQDSTQVTAQVQLVVAAEIDE
EPVSKAKQRRSEKKARKARFKLGLQQVTGVTRVTIRKSKNILFVITKPDVYKSPASDTYM
VFGEAKIEDLSQEAQLAAAEKFKVQGEAVSNIQENTQTPTVQEGSEDEEVDETGVEIKDI
ELVLSQANVWGAKAVRALKNSNDIVNAIMELTM
Target Bioclass
Transporter and channel
Family
TM6SF family
Subcellular location
Lysosome membrane
Function May function as sterol isomerase.
Uniprot ID
Q9BZW5
Ensemble ID
ENST00000322019.14
HGNC ID
HGNC:11860

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
IM95 Deletion: p.L336Ter .
JHH7 SNV: p.P176Q .
OVK18 Deletion: p.L336Ter .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		N.A.  LDD0161  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Fibroblast growth factor receptor 3 (FGFR3) Tyr protein kinase family P22607
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Gelsolin (GSN) Villin/gelsolin family P06396

References

1 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060