Details of the Target

General Information of Target

Target ID LDTP18345
Target Name Putative nascent polypeptide-associated complex subunit alpha-like protein (NACA4P)
Gene Name NACA4P
Synonyms
NACAP1; Putative nascent polypeptide-associated complex subunit alpha-like protein; Alpha-NAC pseudogene 1; NAC-alpha pseudogene 1; NACA family member 4, pseudogene
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEGSNGFGIDSILSHRAGSPALPKGDPLLGDCRSPLELSPRSESSSDCSSPASPGRDCLE
TGTPRPGGASGPGLDSHLQPGQLSAPAQSRTVTSSFLIRDILADCKPLAACAPYSSSGQP
AAPEPGGRLAAKAAEDFRDKLDKSGSNASSDSEYKVKEEGDREISSSRDSPPVRLKKPRK
ARTAFTDHQLAQLERSFERQKYLSVQDRMELAASLNLTDTQVKTWYQNRRTKWKRQTAVG
LELLAEAGNYSALQRMFPSPYFYPQSLVSNLDPGAALYLYRGPSAPPPALQRPLVPRILI
HGLQGASEPPPPLPPLAGVLPRAAQPR
Target Bioclass
Transcription factor
Family
NAC-alpha family
Uniprot ID
Q9BZK3
HGNC ID
HGNC:24688

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
AZ-9
 Probe Info  		D109(10.00)  LDD2209  [1]
HHS-475
 Probe Info  		Y111(0.86)  LDD0264  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0161  [3]
SF
 Probe Info  		K112(0.00); Y111(0.00); K99(0.00)  LDD0028  [4]
HHS-465
 Probe Info  		K112(0.00); Y111(0.00); K107(0.00)  LDD2240  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0116  HHS-0101 DM93 Y111(0.86)  LDD0264  [2]
 LDCM0117  HHS-0201 DM93 Y111(0.79)  LDD0265  [2]
 LDCM0118  HHS-0301 DM93 Y111(0.90)  LDD0266  [2]
 LDCM0119  HHS-0401 DM93 Y111(0.84)  LDD0267  [2]
 LDCM0120  HHS-0701 DM93 Y111(0.74)  LDD0268  [2]

References

1 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
2 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
5 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010